Investigation of Dinoflagellate Populations and Okadaic Acid

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CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = … (3). Okadaic acid has also been described as a non-TPA type potent tumor promoter (4). These tumor-promoting properties and its ability to significantly increase protein phosphorylation make okadaic acid a very useful tool for studying cellular processes that are regulated by reversible phosphorylation of proteins (5). Molecular Formula: C 44 H 68 O 13 Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum and Dinophysis.

Okadaic acid

InSolution Okadaic Acid, Prorocentrum sp. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = … (3). Okadaic acid has also been described as a non-TPA type potent tumor promoter (4). These tumor-promoting properties and its ability to significantly increase protein phosphorylation make okadaic acid a very useful tool for studying cellular processes that are regulated by reversible phosphorylation of proteins (5).

This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 OKADAIC ACID SODIUM SALT. 209266-80-8. MFCD00210208.

459618 Produktnamn: Okadaic Acid, Potassium Salt REACH

Ibelings BW, Chorus I. Accumulation of 24 mars 2003 — dynamics and management of okadaic acid (diarrhoeic shellfish toxin) in blue mussels, Mytilus edulis” fredagen den 28 mars 2003, kl 10.00. okadaic acid and dinophysistoxins: a hydrolysis step may be required to detect the presence of DTX. Okadasyra och dinophysistoxiner: en hydrolysfas kan Nyckelord: MEDICIN; MEDICINE; okadaic acid protein phosphatases IL-1beta TNF-alpha mitogen-activated protein kinases protein kinase C macrophages A single mouse bioassay involving acetone extraction may be used to detect okadaic acid, dinophysistoxins, azaspiracids, pectenotoxins and yessotoxins.

OKADAIC ACID - Dissertations.se

Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp..Okadaic Acid is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC 50 = 10-15 nM).

pressmeddelande. We have developed a cellular model where apparently authentic PHF-like tau hyperphosphorylation is induced by okadaic acid. To gain deeper insight into the av X Huang · 2018 · Citerat av 30 — A fluorescein derivative of okadic acid ligated at the carboxylate T. Structure-activity relationship within a series of okadaic acid derivatives. Maynes, Kathy S. (2001). ”Crystal structure of the tumorpromoter okadaic acid bound to protein phosphatase-1”. Journal of Biological Chemistry.
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As it turns out, in the brain it hyperphosphorylates tau, which causes it to tangle. Okadaic acid-treatment applied to cultures containing predominantly differentiated chondrocytes (after day 4) did not influence the cartilage formation. 3H-thymidine and bromodeoxyuridine incorporation-assays demonstrated enhanced cell proliferation in the okadaic acid-treated colonies compared to that of the untreated ones. Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates.

Search and download thousands of Swedish university dissertations. Full text. Free. The chemicals assessed in the studies included the neurotoxicants methylmercury, okadaic acid and acrylamide, the drug of abuse MDMA (“ecstasy”) and a Talrika exempel på översättningar klassificerade efter aktivitetsfältet av “okadaic acid” – Engelska-Svenska ordbok och den intelligenta översättningsguiden. Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima.
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OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. EuroProxima Okadaic Acid is a competitive enzyme immunoassay for quantitative analysis of domoic acid in scallop, mussel and oyster samples. General information: High concentrations of shellfish toxins can accumulate in filter feeders such as clams, mussels, and oysters causing illness amongst people who eat them.

An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells. This page in English. Författare:.
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A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. Sammanfattning: Bivalve molluscs accumulate toxins of the okadaic acid (OA) and pectenotoxin (PTX) groups, which are frequently found in Dinophysis spp. Okadaic acid (OA) is a lipophilic phycotoxin, which accumulates in the digestive organs of mussels and may cause diarrhetic shellfish poisoning (DSP) in humans. An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells. This page in English. Författare:.

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Investigation of Dinoflagellate Populations and Okadaic Acid

Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 ( PP1 ), PP2A and PP3 inhibitor with IC50 s of 10-15 nM, 0.5 nM and 4 nM, respectively. [1] [2] Okadaic acid eliminate metazoan symbionts/ parasites by apoptosis [3] . Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.

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PP2A is completely inhibited at 1-2 nM, compared to greater than 1 µM for PP1 (1). InSolution Okadaic Acid, Prorocentrum sp. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM). Sigma-Aldrich Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai.

Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively [1]. Protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) are two major mammalian serine/threonine protein phosphatases and are activated in response to Ca2+ cascades as well as increased protein kinase A activity [2]. Okadaic acid is a toxic polyether compound of a C 38 fatty acid (Fig. 1).It is isolated from the black sponge, Halichondria okadai (Kadota), however, it is thought to be produced by marine dinoflagellates that attach to the black sponge. Okadaic acid is a polyether derivative of 38-carbon fatty acid, and is implicated as the causative agent of diarrhetic shellfish poisoning.